Nomoro ea Cetilistat Cas: 282526-98-1 Foromo ea molek'hule:C25H39NO3
| Melting Point | 72.0 ho isa ho 76.0 °C |
| Botenya | 1.02 |
| mocheso oa polokelo | E koaletsoe sebakeng se omileng, 2-8 ° C |
| ho qhibiliha | Chloroform (Hanyenyane), Ethyl Acetate (Hanyenyane) |
| tshebetso ya mahlo | N/A |
| Ponahalo | Kryst e tšoeu |
| Bohloeki | ≥98% |
Cetilistat (eo hape e tsejoang e le ATL-962) e amohetsoe ka Loetse 2013 ke Lekala la Bophelo, Mosebetsi le Boiketlo ba Japane bakeng sa kalafo ea botenya, e lekanyelitsoeng ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 mellitus (T2DM) le dyslipidemia, le boima ba 'mele. index (BMI)25 kg/m2ho sa tsotellehe phekolo ea lijo le/kapa phekolo ea boikoetliso.Joalo ka orlistat, cetilistat e sebetsa ka ho thibela pancreatic lipases ka maleng ho thibela ho monya ha mafura mme ka hona e fokotsa ho kenngoa ha caloric lijong.Lenaneo la k'hemistri ea meriana ha le e-so hlalosoe libukeng tsa mahlale, empa patent e hlalosang cetilistat e boetse e hlalosa ho qaptjoa ha li-analogue tse nang le li-aryl substituents le mehatla ea lipophilic.Sebopeho sa cetilistat se kenyelletsa condensation ea hexadecylcarbonochloridate le 2-amino-5-methylbenzoic acid;li-analogue tse ling li ile tsa etsoa ka ho fapanyetsana likarolo tsa carbonochloridate le 2-aminobenzoic acid.Cetilistat ke inhibitor e matla ea motho le rat pancreatic lipase e nang le IC50sea 15 le 136 nM, ka ho latellana, ka ho thibela ho fokolang ha trypsin kapa chymotrypsin.
Novel pancreatic lipase inhibitor bakeng sa kalafo ea botenya ho bakuli ba nang le lefu la tsoekere le bao e seng ba lefu la tsoekere.
Botsa Ngaka keletso pele
