Nomoro ea Rifampicin Cas: 13292-46-1 Foromo ea molek'hule: C43H58N4O12

Rifampicin ke motsoako oa semisynthetic oa rifamicin B, lithibela-mafu tsa macrolactam le e 'ngoe ea lithibela-mafu tse fetang tse hlano tse tsoang motsoakong oa rifamicins A, B, C, D, le E, e bitsoang rifamicin complex, e hlahisoang ke actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).E ile ea kenngoa ts'ebetsong ea bongaka ka 1968. Synthesis ea rifampicin e qala ka tharollo ea metsi ea rifamicin, eo tlas'a maemo a karabelo e leng oxidized ho e ntjha e ntjha ya rifamicin S (32.7.4), ka sebopeho sa mahareng sa rifamicin O (32.7. 3).Ho fokotsa sebopeho sa quinone sa sehlahisoa sena ka haedrojene ho sebelisa palladium ho catalyst ea khabone ho fana ka rifamicin SV (32.7.5).Sehlahisoa se hlahisoang se feta aminomethylation ka motsoako oa formaldehyde le pyrrolidine, ho fana ka 3-pyrrolidinomethylrifamicin SV (32.7.6).Ho etsa oxidizing sehlahisoa se hlahisoang ka tetracetate ea lead ho enamine le hydrolysis e latelang e nang le tharollo e nang le metsi a ascorbic acid e fana ka 3-formylrifamicin SV (32.7.7).Ho arabela sena ka 1-amino-4-methylpiperazine ho fana ka rifampicin e lakatsehang (32.7.8).