l Nomoro ea Cas: 171596-29-5 Foromo ea molek'hule: C₂₂H₁₉N₃O₄
| Melting Point | >193°C |
| Botenya | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| mocheso oa polokelo | -20°C |
| ho qhibiliha | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| tshebetso ya mahlo | [α]/D +68 ho +78°, c = 1 ka chloroform-d |
| Ponahalo | Bosoeu ho isa ho bosoeu bo Tiileng |
| Bohloeki | ≥98% |
(lebitso la mmaraka kapa) ke mofuta oa PDE5 inhibitor e sebelisetsoang ho phekola ho se sebetse hantle ha erectile, benign prostatic hypertrophy le pulmonary arterial hypertension.Phello ea ke ho khatholla mesifa ea methapo ea mali le ho eketsa phallo ea mali ho corpus cavernosum.Mokhoa oa ketso oa ke ka ho thibela ts'ebetso ea cGMP e khethehileng ea phosphodiesterase mofuta oa 5 (PDE5).PDE5 e theola cGMP ka har'a corpus cavernosum e haufi le botona.Ka hona, tadalafi e lebisa tlhokomelong e eketsehileng ea cGMP e bakang ho phomola ha mesifa e boreleli le ho eketseha ha mali ho corpus cavernosum.Liphuputso tse ling tsa bongaka li boetse li fana ka maikutlo a hore li ka ntlafatsa ts'ebetso ea endothelia ho banna ba nang le kotsi e eketsehileng ea pelo le ho fokotsa matšoao a moroto a bobeli ho benign prostatic hyperplasia.
lithethefatsi tse thibelang bohloko, li-blocker tsa ho amohela, mu-opiod receptor agonist.Phosphodiesterase 5 inhibitor.e sebelisoa ho phekola ho se sebetse hantle ha erectile.
e fapane ka sebopeho ho tloha ho sildenafil le vardenafil.E kenella ka potlako 'me e fihla tlhorong ea mahloriso (378 μg/L ka mor'a tekanyo ea 20-mg) ka mor'a lihora tse peli, e bonts'a halofo ea bophelo ba lihora tse 17.5.E boetse e sebelisoa ke sebete (CYP3A4).Haholo-holo, pharmacokinetics ea eona ha e susumetsoe ke joala kapa lijo kapa lintho tse kang lefu la tsoekere kapa ho se sebetse hantle ha sebete kapa renal.
