Nomoro ea Cas: 144701-48-4 Foromo ea Limolek'hule:C33H30N4O2 Setšoantšo se Featured

Nomoro ea Cas: 144701-48-4 Foromo ea molek'hule: C33H30N4O2

Tlhaloso e Khutšoanyane:

Nomoro ea Cas: 144701-48-4
Lebitso la lik'hemik'hale:
Mokhoa oa molek'hule: C33H30N4O2

Mantsoe a tšoanang: MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

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Tlhaloso ea Lihlahisoa

Melting Point	261-263°C
Botenya	1.16 (khakanyo e fosahetseng)
mocheso oa polokelo	Sepakapaka se sa tsitsang, Mocheso oa Kamore 2-8°C
ho qhibiliha	DMSO: > 5 mg/mL ho 60 °C
tshebetso ya mahlo	N/A
Ponahalo	Hantle-Bosoeu Tiileng
Bohloeki	≥98%

Tlhaloso

e ile ea qalisoa United States bakeng sa phekolo ea khatello ea mali.E ka lokisoa ka mehato e robeli ho qala ka methyl 4-amino-3-methyl benzoate;cyclization ea pele le ea bobeli ho lesale la benzimidazole li etsahala mehatong ea 4 le ea 6 ka ho latellana.e thibela ketso ea angiotensin II (Ang II), molek'hule ea mantlha ea renin-angiotensin-aldosterone system (RAAS).Ke sehlopha sa botšelela sa sehlopha sena sa 《sartans》 se tlang ho rekisoa ka mor'a motsoako oa lead Losartan.Phello ea eona e tšoarellang nako e telele (24h halofo ea bophelo) e ka ba phapang e kholo le bahanyetsi ba bang ba angiotensin II.Ho fapana le mahlahana a mang a 'maloa sehlopheng sena, ts'ebetso ea eona ha e itšetlehe ka phetoho ho metabolite e sebetsang, 1-O-acylglucuronide e le eona metabolite e ka sehloohong e fumanoang ho batho.ke mohanyetsi ea matla oa tlholisano oa li-receptor tsa AT1 tse lipakeng angiotensin II ha e ntse e haelloa ke kamano bakeng sa li-subtypes tsa AT2 kapa li-receptor tse ling tse amehang taolong ea pelo.Lithutong tse 'maloa tsa kliniki, ka tekanyetso e le' ngoe ea letsatsi le letsatsi, li hlahisitse litlamorao tse sebetsang le tse tsitsitseng tsa ho theola khatello ea mali ka sekhahla se tlase sa litlamorao (haholo-holo ho khohlela ho amanang le kalafo ho amanang le ACE inhibitors ho bakuli ba tsofetseng).